期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Redox control of NLRP3 inflammasome activation in health and disease | |
| 关键词: caspase‐; 1; IL‐; 1β; IL‐; 1 receptor antagonist; leaderless secretion; oxidative stress; ROS; antioxidants; | |
| DOI : 10.1189/jlb.0512265 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
ShiftsintheredoxbalancebetweenROSandantioxidantsregulateinnateimmunityatvariouslevels.ChangesintheredoxmicroenvironmentmodulatetheactivationpotentialoftheNLRP3inflammasome,asignalingplatformthatactivatescaspase‐1,allowingthematurationofIL‐1β.However,acleardefinitionoftheunderlyingmechanismismissing.Inthisessay,Ireviewthemost‐creditedtheoriesoninflammasomeactivation.Inparticular,Iwillfocusontheredox‐mediatedmechanismsthatregulatetheassemblyofNLRP3inflammasomeanddiscusshowaberrationsinthemareimplicatedinthepathogenesisofautoinflammatorydiseases...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901238292591ZK.pdf | 996KB |  download |
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