American Journal of Cardiovascular Disease | |
Inflammasomes in cardiovascular diseases | |
Nisha Jain Garg1  | |
关键词: Cardiovascular diseases; inflammasomes; reactive oxygen species; Interleukin 1 beta; Nod-like receptors; | |
DOI : | |
学科分类:心脏病和心血管学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
NOD-like receptors (NLRs) constitute a recently identified family of macromolecules that participate in regulation of innate immune responses. To date, 23 members of the NLR family are identified in humans. Diverse NLRs are stimulated by a broad range of pathogen- or danger-associated molecular patterns, and collectively function as intracellular pattern recognition receptors (PRRs). The most studied inflammasomes are NLRP1 and NLRP3 that process inactive pro-caspase-1 to its active form, allowing the cleavage and subsequent activation of pro-IL-1β and pro-IL-18, and initiation of inflammatory responses. Three models, based upon extracellular ATP/K+ flux, lysosomal release of cathepsin, and reactive oxygen species, have been proposed to be involved in signaling activation of NLRs and downstream events. In this review, I discuss the current state of knowledge related to the roles of NLRs and inflammasomes in the development of cardiovascular diseases.
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO201901238175068ZK.pdf | 155KB | download |