期刊论文详细信息
| International Journal of Clinical and Experimental Pathology | |
| The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia | |
| Cheng Wang1 | |
| 关键词: TP53 network; microRNAs; chronic lymphocytic leukemia; pathogenesis; | |
| DOI : | |
| 学科分类：生理学与病理学 | |
| 来源: e-Century Publishing Corporation | |
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【 摘 要 】
TP53 is one of the most important prognostic factors in chronic lymphocytic leukemia (CLL). Modulation of microRNAs by TP53 in CLL pathogenesis has been a hotspot. Besides, it has an intimate association with other cytogenetics and plays an important part in drug resistance of CLL. All above indicate an embedded TP53-centered network in CLL pathogenesis and prognosis. In this review, we focus on the TP53-centered network and its roles in the pathogenesis of CLL.
【 授权许可】
CC BY-NC
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901238102753ZK.pdf | 384KB |  download |
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