Neutrophil plasticity: acquisition of phenotype and functionality of antigen‐presenting cell

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: dendritic cell;    inflammation;   

DOI  :  10.1189/jlb.1MR1014-502R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Accumulatinglinesofevidencenowdemonstratethatneutrophilscanparticipateinadaptiveimmuneresponsesdirectlyorindirectly.EvenmorestrikingistheirpotentialtoacquirephenotypicandfunctionalpropertiesthataretypicallyreservedforprofessionalAPCs.Thesenewlyemergingconceptsofneutrophilheterogeneityandplasticitynowchallengetheclassicviewofneutrophilsasterminallydifferentiatedleukocytesfullycommittedtophagocytefunctionality.Here,wepresentabriefoverviewofourcurrentunderstandingofneutrophilplasticitybyfocusingontheacquisitionofDC‐likepropertiesincultureandatsitesofinflammation.HumanandmurineneutrophilsacquiresurfaceexpressionofMHCII,costimulatorymolecules,andothersurfacemarkersofDCswhenculturedinthepresenceofselectedcytokines.TheresultingpopulationsalsoexhibitpotentAPCactivitiestopresentvariousantigenstoTcells.“Unusual”neutrophilsexpressingDCmarkershavebeendetectedininflammatorylesionsinhumanpatientsandmousediseasemodels.ThesefindingsimplythatacquisitionofDC‐likepropertiesbyneutrophilsatthesitesofinflammationmayrepresentakeyprocessforlinkingtheinnateandadaptivearmsofimmuneresponses...

【 授权许可】

CC BY