| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| CRIg mediates early Kupffer cell responses to adenovirus | |
| 关键词: complement; phagocytosis; liver sinusoidal endothelial cell; Intravital microscopy; cell death; innate immunity; infection; | |
| DOI : 10.1189/jlb.0612311 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Whereasadenoviralvectorsareknowntoactivatethecomplementcascade,leadingtofixationofC3proteinstotheviralcapsid,theconsequencesofthisactivationforviralclearancefromthecirculationarenotknown.LiverKCs,themacrophagepopulationresponsibleforearlyuptakeandeliminationofmanyblood‐bornepathogens,expressCRIg,acomplementreceptorforC3proteins.Here,wefindthatCRIgisimportantfortheearlyeliminationofC3‐coatedadenoviralvectorsfromthesinusoidalbloodstreambyKCs.Wefurtherdemonstratethatbyactingasacriticalreceptorforadenovirusphagocytosis,CRIgplaysanimportantroleinregulatingvirus‐inducedKCdeathanddepletionofthesecellsfromtheliversinusoidallumen.OurstudythusidentifiesacriticalpathwayregulatingKCfunctionandsurvivalinresponsetosystemicviralinfection...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901237839142ZK.pdf | 1567KB |  download |
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