Increased plasmacytoid dendritic cells and RORγt‐expressing immune effectors in cutaneous acute graft‐versus‐host disease

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: allogeneic stem cell transplantation;    Th17 cells;    Type I Interferon;   

DOI  :  10.1189/jlb.0513295

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

TheroleofPDCsandTh17cellsisnotwellunderstoodinthepathogenesisofaGVHD.WeevaluatedPDCandTh17cellsinskinbiopsiesof38patientsatdiagnosisofaGVHD.ThebiopsiesweretestedbyimmunohistochemistryfortheexpressionofBDCA2,atypicalmarkerofPDCs.WefoundanincreaseofBDCA2+cellsintheskinofthepatientswithaGVHD.Moreover,weobservedastrongexpressionofthetypeIIFN‐inducibleproteinMx1intheskinofthepatientswithaGVHD,comparedwiththatofthosewithoutit,suggestingthatPDCsproducetypeIIFN.WealsoanalyzedtheexpressionoftwoTh17surfacemarkers—CD161andCCR6—andRORγt,thekeytranscriptionfactorthatorchestratesthedifferentiationofTh17cells.SignificantlyhighernumbersofRORγt+,CD161+,andCCR6+cellswerecountedintheskinofthepatientswithaGVHDthanintheskinofthosewhounderwentallo‐SCTandinwhomaGVHDdidnotdevelop.ThisstudyprovidesevidenceforaroleofTh17‐mediatedresponsesandapotentialnewpathophysiologicallinkbetweenPDCsandTh17inhumancutaneousaGVHD...

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