IL‐17+Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and regulatory T cells

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: RORγ;    t;    immune system;    inflammation;    tumor microenvironment;   

DOI  :  10.1189/jlb.1RU0114-010RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Foxp3+Tregshavebeenknownasamajorregulatorofimmunehomeostasisthroughtheirimmunosuppressivefunction.Th17lineageisaCD4+Tcellsubsetthatexertsitsfunctionbysecretingproinflammatorycytokinesandprotectinghostagainstmicrobialinfections.ThealteredratiobetweenFoxp3+TregsandTh17cellsplaysanimportantroleinthepathogenesisofimmune‐relateddiseases.RecentmiceandhumanstudieshavedemonstratedthatTregscanbereprogrammedintoanovelpopulation,IL‐17+Foxp3+Tcells,phenotypicallyandfunctionallyresemblingTh17cellsunderthecomplicatedcytokinestimulation.TheidentificationofIL‐17+Foxp3+TcellsmayprovideanewunderstandingoftherapytargetingTregsandTh17cellsinautoimmunediseasesandcancer.Here,wehighlightsignificantdataregardingthephenotypeprofile,origination,differentiation,andthepleiotropicfunctionsofIL‐17+Foxp3+TcellsandthereciprocalrelationshipsofthesecellstoTregsandTh17cells.Furthermore,theroleofIL‐17+Foxp3+Tcellsintumorigenesisandclinicalimplicationsincancertherapyarediscussedinthisreview...

【 授权许可】

CC BY