Microdomains in the membrane landscape shape antigen‐presenting cell function

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: B cell antigen receptor;    major histocompatibility complex class II;    pattern recognition receptor;    tetraspanin;    signal transduction;   

DOI  :  10.1189/jlb.0813440

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Theplasmamembraneofimmunecellsisahighlyorganizedcellstructurethatiskeytotheinitiationandregulationofinnateandadaptiveimmuneresponses.Itiswell‐establishedthatimmunoreceptorsembeddedintheplasmamembranehaveanonrandomspatialdistributionthatisimportantforcouplingtocomponentsofintracellularsignalingcascades.Inthelasttwodecades,specializedmembranemicrodomains,includinglipidraftsandTEMs,havebeenidentified.Thesedomainsarepreformedstructures(“physicalentities”)thatcompartmentalizeproteins,lipids,andsignalingmoleculesintomultimolecularassemblies.InAPCs,differentmicrodomainscontainingimmunoreceptors(MHCproteins,PRRs,integrins,amongothers)havebeenreportedthatareimperativeforefficientpathogenrecognition,theformationoftheimmunologicalsynapse,andsubsequentTcellactivation.Inaddition,recentworkhasdemonstratedthattetraspaninmicrodomainsandlipidraftsareinvolvedinBCRsignalingandBcellactivation.Researchintothemolecularmechanismsunderlyingmembranedomainformationisfundamentaltoacomprehensiveunderstandingofmembrane‐proximalsignalingandAPCfunction.Thisreviewwillalsodiscusstheadvancesinthemicroscopyfieldforthevisualizationoftheplasmamembrane,aswellastherecentprogressintargetingmicrodomainsasnovel,therapeuticapproachforinfectiousandmalignantdiseases...

【 授权许可】

CC BY