The emerging role of protein kinase Cθ in cytoskeletal signaling

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: cytoskeleton;    immunological synapse;    membrane translocation;    spectrin aggregate;   

DOI  :  10.1189/jlb.0812371

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Cytoskeletalrearrangementsoftenoccurastheresultoftransductionofsignalsfromtheextracellularenvironment.Efficientawakeningofthispowerfulmachineryrequiresmultipleactivationanddeactivationsteps,whichusuallyinvolvephosphorylationordephosphorylationofdifferentsignalingunitsbykinasesandphosphatases,respectively.Inthisreview,wediscussthesignalingcharacteristicsofoneofthenPKCisoforms,PKCθ,focusingonPKCθ‐mediatedsignaltransductiontocytoskeletalelements,whichresultsincellularrearrangementscriticalforcelltype‐specificresponsestostimuli.PKCθisthemajorPKCisoformpresentinhematopoieticandskeletalmusclecells.PKCθplaysrolesinTcellsignalingthroughtheIS,survivalresponsesinadultTcells,andTcellFasL‐mediatedapoptosis,allofwhichinvolvecytoskeletalrearrangementsandrelocationofthisenzyme.PKCθhasbeenlinkedtotheregulationofcellmigration,lymphoidcellmotility,andinsulinsignalingandresistanceinskeletalmusclecells.AdditionalrolesweresuggestedforPKCθinmitosisandcell‐cycleregulation.Comprehensiveunderstandingofcytoskeletalregulationandthecellular“modusoperandi”ofPKCθholdspromiseforimprovingcurrenttherapeuticapplicationsaimedatautoimmunediseases...

【 授权许可】

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