期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Bromodomain 4: a cellular Swiss army knife | |
| 关键词: BRD4; kinase; Pol II; acetyltransferase; nucleosome eviction; | |
| DOI : 10.1189/jlb.2RI0616-250R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Bromodomainprotein4(BRD4)isatranscriptionalandepigeneticregulatorthatplaysapivotalroleincancerandinflammatorydiseases.BRD4bindsandstaysassociatedwithchromatinduringmitosis,bookmarkingearlyG1genesandreactivatingtranscriptionaftermitoticsilencing.BRD4playsanimportantroleintranscription,bothasapassivescaffoldviaitsrecruitmentofvitaltranscriptionfactorsandasanactivekinasethatphosphorylatesRNApolymeraseII,directlyandindirectlyregulatingtranscription.ThroughitsHATactivity,BRD4contributestothemaintenanceofchromatinstructureandnucleosomeclearance.ThisreviewsummarizestheknownfunctionsofBRD4andproposesamodelinwhichBRD4activelycoordinateschromatinstructureandtranscription...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901236760593ZK.pdf | 755KB |  download |
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