Impact of Inflammation on the Onset and Severity of Vascular Disease in Patients with Ankylosing Spondylitis

Current Health Sciences Journal

DIANA-RODICA TUDORASCUreplacement¹ 

关键词: ankylosing spondylitis;    atherosclerosis;    inflammation;    endothelial dysfunction;    vascular disease;   

DOI  :  10.12865/CHSJ.37.02.05

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Ankylosing spondylitis associates an increase in morbidity and mortality from cardiovascular disease, existing a defined relationship between cardiovascular diseases and ankylosing spondylitis. Recent studies reported impairment of endothelial function, suggesting that atherosclerosis (ATS) induced by systemic chronic inflammation and altered lipid profile could be responsible of cardiovascular mortality increase. We assessed the role of inflammation in the induction and severity of vascular disease in patients with ankylosing spondylitis. We included 73 patients with no other vascular risk factors and assessed subclinical ATS at common carotid artery, the involvement of aorta, aortic valvular regurgitation and the correlation of these pathological changes with inflammatory status. 21 of the 73 patients (29%) showed different types and degrees of vascular disease which was correlated with pro-inflammatory markers, disease activity and the time from diagnosis. The chronic inflammatory s.

【 授权许可】

Unknown