期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Reactive oxygen species‐mediated bacterial killing by B lymphocytes | |
| 关键词: NADPH oxidase; chronic granulomatous disease; phagocytosis; Nox2; p22phox; | |
| DOI : 10.1189/jlb.4AB1113-607RR | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
RegulatedproductionofROSismainlyattributedtoNoxfamilyenzymes.Inneutrophilgranulocytesandmacrophages,Nox2hasacrucialroleinbacterialkilling,andtheabsenceofphagocyticROSproductionleadstothedevelopmentofCGD.ExpressionofNox2wasalsodescribedinBlymphocytes,wheretheroleoftheenzymeisstillpoorlyunderstood.Here,weshowthatperitonealBcells,whichwereshownrecentlytopossessphagocyticactivity,haveahighcapacitytoproduceROSinaNox2‐dependentmanner.InphagocytosingBcells,intenseintraphagosomalROSproductionisdetected.Finally,bystudying2animalmodelsofCGD,wedemonstratethatphagocyteoxidase‐deficientBcellshaveareducedcapacitytokillbacteria.OurobservationsextendthenumberofimmunecelltypesthatproduceROStokillpathogens...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901236499549ZK.pdf | 869KB |  download |
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