Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis

American Journal of Cardiovascular Disease

Luis M Moura¹ 

关键词: Calcific aortic stenosis;    polymorphism;    paraoxonase;    atherosclerosis;    genetics;    association;   

DOI  :  

学科分类：心脏病和心血管学

来源: e-Century Publishing Corporation

【 摘 要 】

Introduction and ObjectivesParaoxonases may exert anti-atherogenic action by reducing lipid peroxidation. Previous studies examined associations between polymorphisms in the paraoxonase 1 (PON1) gene and development of coronary artery disease (CAD), with inconsistent results. Given the similarities in clinical and pathophysiological risk factors of CAD and calcific aortic valve stenosis (CAVS), we postulated a link between PON1 alleles and CAVS progression.

【 授权许可】

CC BY-NC