Proliferation and apoptosis of Peyer’s patches and its lymphocytes in experimental terminal ileitis

International Journal of Clinical and Experimental Pathology

Wei Wang¹ 

关键词: Cell apoptosis;    lymphocytes;    PP knot;    terminal ileitis;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

This study will provide guide for the terminal ileitis in clinical diagnosis and treatment. The animals were been done terminal ileum-cecum side to side anastomosis, terminal ileum operation line and only anesthesia treatment, respectively. The model group presented acute inflammation after surgery for 2 weeks and the inflammation was limited to the mucosal layer. Animals presented chronic inflammation to 8 weeks, mucosal membrane was given priority to with lymphocytic infiltrates. In 2 weeks and 4 weeks, the number of Peyer’s patches (PP knot) and PP knot lymphocytes increased significantly in the model group (P < 0.05, P < 0.01). At 8 weeks, the suture group and the model group presented a large number of lymphocytic apoptosis (P < 0.01). Rat ileal PP knot lymphocyte small molecule DNA showed typical “trapezoid” bands. We observed apparent morphology of apoptosis and crescent-shaped nucleus. Continuous immune response in terminal ileitis plays a considerable role in the process of the disease.

【 授权许可】

CC BY-NC