Crystal structure of levomepromazine maleate

Acta Crystallographica Section E: Crystallographic Communications

Gá¹  May, N.V.¹  l, G.T.¹ 

[1] Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1519 Budapest, POB 206, Hungary

关键词: CRYSTAL STRUCTURE;    PHENOTHIAZINE;    MALEATE;    HYDROGEN BONDING;    C-H...[PI] INTERACTIONS;   

DOI  :  10.1107/S2056989016004916

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

The asymmetric unit of the title salt, C19H25N2OS+·C4H3O4− [systematic name: (S)-3-(2-meth­oxy­pheno­thia­zin-10-yl)-N,N,2-tri­methyl­propanaminium hydrogen maleate], comprises two (S)-levomepromazine cations and two hydrogen maleate anions. The conformations of the two cations are similar. The major difference relates to the orientation of the meth­oxy substituent at the pheno­thia­zine ring system. The crystal components form a three-dimensional supra­molecular network via N—H⋯O, C—H⋯O and C—H⋯π inter­actions. A comparison of the conformations of the levomepromazine cations with those of the neutral mol­ecule and similar protonated mol­ecules reveals significant conformational flexibility of the pheno­thia­zine ring system and the substituent at the pheno­thia­zine N atom.

【 授权许可】

CC BY