Changes in Central Aortic Pressure, Endothelial Function and Biomarkers in Hypertensive African-Americans with the Cardiometabolic Syndrome: Comparison of Amlodipine/Olmesartan versus Hydrochlorothiazide/Losartan

Cardiorenal medicine

Bobby V. Khan ; Nadya Merchant ; Syed T. Rahman ; Mushtaq Ahmad ; Janice M. Parrott ; Kanwal Umar ; Julie Johnson ; Keith C. Ferdinand

关键词: Cardiometabolic syndrome;    African-Americans;    Compliance;    Inflammation;    Hypertension;   

DOI  :  10.1159/000355136

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Sixty-six self-identified African-American subjects with stage 1 and 2 hypertension and characteristics of the cardiometabolic syndrome were treated with amlodipine/olmesartan (A/O) versus losartan/hydrochlorothiazide (L/H) for 20 weeks in an open-label, active comparator fashion. Subjects not meeting a blood pressure (BP) value of <125/75 mm Hg on either regimen at week 14 were placed on additional or alternative therapy. After 20 weeks of therapy, systolic BP was reduced by 34.6 .

【 授权许可】

CC BY