Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Regulation of inflammation, autoimmunity, and infection immunity by HVEM‐BTLA signaling | |
关键词: costimulation; coinhibition; pathogenesis; | |
DOI : 10.1189/jlb.0910528 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
TheHVEM,orTNFRSF14,isamembrane‐boundreceptorknowntoactivatetheNF‐κBpathway,leadingtotheinductionofproinflammatoryandcellsurvival‐promotinggenes.HVEMbindsseveralligandsthatarecapableofmediatingcostimulatorypathways,predominantlythroughitsinteractionwithLIGHT(TNFSF14).However,itcanalsomediatecoinhibitoryeffects,predominantlybyinteractingwithIGSFmembers,BTLAorCD160.Therefore,itcanfunctionlikea“molecularswitch”forvariousactivatingorinhibitoryfunctions.Furthermore,recentstudiessuggesttheexistenceofbidirectionalsignalingwithHVEMactingasaligandforsignalingthroughBTLA,whichmayactasaligandinothercontexts.Bidirectionalsignaling,togetherwithnewinformationindicatingsignalingincisbycellsthatcoexpressHVEManditsligands,makessignalingwithinaHVEM‐mediatednetworkcomplicated,althoughpotentiallyrichinbiology.AccumulatinginvivoevidencehasshownthatHVEM‐mediated,coinhibitorysignalingmaybedominantoverHVEM‐mediatedcostimulatorysignaling.InseveraldiseasemodelstheabsenceofHVEM‐BTLAsignalingpredominantlyresultedinseveremucosalinflammationinthegutandlung,autoimmune‐likedisease,andimpairedimmunityduringbacterialinfection.Here,wewillsummarizethecurrentviewabouthowHVEM‐BTLAsignalingisinvolvedintheregulationofmucosalinflammation,autoimmunity,andinfectionimmunity...
【 授权许可】
CC BY
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