Regulation of inflammation, autoimmunity, and infection immunity by HVEM‐BTLA signaling

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: costimulation;    coinhibition;    pathogenesis;   

DOI  :  10.1189/jlb.0910528

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

TheHVEM,orTNFRSF14,isamembrane‐boundreceptorknowntoactivatetheNF‐κBpathway,leadingtotheinductionofproinflammatoryandcellsurvival‐promotinggenes.HVEMbindsseveralligandsthatarecapableofmediatingcostimulatorypathways,predominantlythroughitsinteractionwithLIGHT(TNFSF14).However,itcanalsomediatecoinhibitoryeffects,predominantlybyinteractingwithIGSFmembers,BTLAorCD160.Therefore,itcanfunctionlikea“molecularswitch”forvariousactivatingorinhibitoryfunctions.Furthermore,recentstudiessuggesttheexistenceofbidirectionalsignalingwithHVEMactingasaligandforsignalingthroughBTLA,whichmayactasaligandinothercontexts.Bidirectionalsignaling,togetherwithnewinformationindicatingsignalingincisbycellsthatcoexpressHVEManditsligands,makessignalingwithinaHVEM‐mediatednetworkcomplicated,althoughpotentiallyrichinbiology.AccumulatinginvivoevidencehasshownthatHVEM‐mediated,coinhibitorysignalingmaybedominantoverHVEM‐mediatedcostimulatorysignaling.InseveraldiseasemodelstheabsenceofHVEM‐BTLAsignalingpredominantlyresultedinseveremucosalinflammationinthegutandlung,autoimmune‐likedisease,andimpairedimmunityduringbacterialinfection.Here,wewillsummarizethecurrentviewabouthowHVEM‐BTLAsignalingisinvolvedintheregulationofmucosalinflammation,autoimmunity,andinfectionimmunity...

【 授权许可】

CC BY