IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: IL‐;    28;    IL‐;    6;    microarray analysis;    ISG;   

DOI  :  10.1189/jlb.0212064

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

ThePRRTLR7playsakeyroleintheactivationofautoantigen‐reactiveBcells.ThisresponseisincreasedmarkedlybyIFN‐α,producedbyaccessorycells,asaresultoftheup‐regulationofTLR7.WereporthereinanalternativepathwaybywhichTLR7expressioncanbeaugmented.ThisfindingwasderivedfromcontinuationofongoingstudiestouncoverinteractionsbetweenNKandBcells.Here,wehavecomparedgeneexpressionprofilesbymicroarrayanalysisofBcellsbeforeandaftertheirinteractionwithpurifiedNKcells.ThemostoutstandingalterationofgenestranscribedinBcellsisasignificantincreaseintheexpressionofmanymembersoftheISGfamily,amongwhichisTLR7.FurtheranalysisrevealedthattheenhancementofTLR7onBcellsisnotmediatedviatypeIortypeIIIFNbutbyanothercytokine,IL‐28,atypeIIIIFN,whichactsinconcertwithcontact‐mediatedinteractionswithNKcells.ThisincreasedexpressionallowsBcellstorespondmorereadilyuponstimulationbyitsligandandmayincreaseinvivoresponsestootherTLR7ligands,suchasautoantigens,priortoorjointlywithstimulationbyothercytokines...

【 授权许可】

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