| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Role of CD27/CD70 pathway of activation in immunity and tolerance | |
| 关键词: costimulation; immune regulation; T cell differentiation; memory responses; viral infections; | |
| DOI : 10.1189/jlb.0610351 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
TheCD70/CD27axishasgainedincreasinginterestamongtheimmunologists,becauseofitscapacitytoregulateimmunityversustolerance.RecentstudiesclearlyshowthatexpressionofCD70maypreventtoleranceinducedbyantigenpresentationinthesteady‐state,i.e.,bynonactivatedDCs.Inaddition,CD27signalingappearscriticalforTcellexpansionandsurvivalandtherefore,inductionoflong‐termmemory.Itcontributestogerminalcenterformation,Bcellactivation,andproductionofneutralizingantibodiesbutcanalsobesubvertedbyviruses,inparticular,duringchronicinfections.ThepotentialroleoftheCD27/CD70pathwayinthecourseofinflammatorydiseases,asinEAE,arthritis,andinflammatoryboweldiseasemodels,suggeststhatCD70maybeatargetforimmuneintervention.Conversely,thepotencyofcostimulationthroughCD27suggeststhattheCD27/CD70axiscouldbeexploitedforthedesignofanti‐cancervaccines...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901235368608ZK.pdf | 440KB |  download |
878987797
028-85220240
