Emerging roles of pulmonary macrophages in driving the development of severe asthma

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: innate immunity;    airway hyper‐;    responsiveness;    steroid resistance;   

DOI  :  10.1189/jlb.0711357

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Asthmaisrecognizedasaheterogeneousdisorder,althoughinmostpatients,theclinicalmanifestationsareeffectivelymanagedwithestablishedcombinationtherapies.However,5–10%ofasthmaticshavesevereasthma,whichdoesnotrespondtotreatment,andthesepatientsaccountfor>50%ofasthma‐relatedhealthcarecosts.Newinvestigationsintothepathogenesisofglucocorticoidresistanceinsevereasthmaindicatethatpulmonarymacrophagesmayplaycentralrolesinpromotingairwayinflammation,particularlyinasthmathatisresistanttosteroidtherapy.Importantly,factorsthatarelinkedtotheactivationofpulmonarymacrophagesmaycontributetoglucocorticoidresistanceandsevereasthma.Here,wereviewrecentadvancesinunderstandingtherolesofpulmonarymacrophagesinthemechanismsofglucocorticoidresistanceandthepathogenesisofsevereasthma.Wediscusstheroleofmacrophagephenotype,infection,IFN‐γ,LPS,associatedsignalingpathways,TNF‐α,MIF,andothermacrophage‐associatedfactors.Understandingthepathogenesisofsteroid‐resistantsevereasthmawillcontributetotheidentificationofoptimaltherapeuticstrategiesfortheeffectivemanagementofthedisease...

【 授权许可】

CC BY