Liver X Receptor α Inhibits Osteosarcoma Cell Proliferation through Up-Regulation of FoxO1

Cellular Physiology and Biochemistry

关键词: Osteosarcoma;    LXRα;    FoxO1;    Transcription;   

DOI  :  10.1159/000350134

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Background Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. Methods We analyzed liver X receptor α (LXRα) mRNA expression in 16 pairs of human osteosarcoma tissues and adjacent noncancerous tissues. Moreover, we investigated LXRα's potential role in regulating cell proliferation in Saos-2 and U2OS cells. Results We found that activation of LXRα, a member of nuclear receptor, was able to inhibit cell proliferation in Saos-2 and U2OS cells. At the molecular level, our results further revealed that expression of tumor suppressor gene, FoxO1, was up-regulated by LXRα activation. LXRα activates FoxO1 transcription through a direct binding on its promoter region. Conclusion LXRα acts as a tumor suppressor for osteosarcoma, which may offer a new way in molecular targeting cancer treatment.

【 授权许可】

CC BY-NC-ND