Interferon‐γ—central mediator of protective immune responses against the pre‐erythrocytic and blood stage of malaria

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: human;    falciparum;    cytokine;    innate;    adaptive;    vaccine;   

DOI  :  10.1189/jlb.0310137

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

ImmuneresponsesagainstPlasmodiumparasites,thecausativeorganismsofmalaria,aretraditionallydichotomizedintopre‐erythrocyticandblood‐stagecomponents.Whereasthecentralroleofcellularresponsesinpre‐erythrocyticimmunityiswellestablished,protectionagainstblood‐stageparasiteshasgenerallybeenascribedtohumoralresponses.Anumberofrecentstudies,however,havehighlightedtheexistenceofcellularimmunityagainstblood‐stageparasites,inparticular,theprominenceofIFN‐γproduction.Here,wehaveundertakentochartthecontributionofthisprototypicalcellularcytokinetoimmunityagainstpre‐erythrocyticandblood‐stageparasites.WesummarizethevariousantiparasiticeffectorfunctionsthatIFN‐γservestoinduce,reviewanarrayofdataaboutitsprotectiveeffects,andscrutinizeevidenceforanydeleterious,immunopathologicaloutcomeinmalariapatients.WediscusstheactivationandcontributionofdifferentcellularsourcesofIFN‐γproductionduringmalariainfectionanditsregulationinrelationtoexposure.WeconcludethatIFN‐γformsacentralmediatorofprotectiveimmuneresponsesagainstpre‐erythrocyticandblood‐stagemalariaparasitesandidentifyanumberofimplicationsforrationalmalariavaccinedevelopment...

【 授权许可】

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