CXCL13 is elevated in Sjögrenˈs syndrome in mice and humans and is implicated in disease pathogenesis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: B‐;    cell;    CXCR5;    saliva;    sialadenitis;   

DOI  :  10.1189/jlb.0113036

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

SSisanautoimmunedisease.pSSaffectsexocrineglandspredominantly,whereassSSoccurswithotherautoimmuneconnectivetissuedisorders.Currently,careforpatientswithSSispalliative,asnoestablishedtherapeuticstargetthediseasedirectly,anditspathogeneticmechanismsremainuncertain.B‐cellabnormalitieshavebeenidentifiedinSS.CXCL13directsB‐cellchemotaxisandiselevatedinseveralautoimmunediseases.Inthisstudy,wetestedthehypothesisthatCXCL13iselevatedinSSinmiceandhumansandthatneutralizationofthechemokineamelioratesdiseaseinamurinemodel.WeassayedCXCL13inmousemodelsandhumansubjectswithSStodeterminewhetherCXCL13iselevatedbothlocallyandsystemicallyduringSSprogressionandwhetherCXCL13mayplayaroleinandbeabiomarkerforthedisease.Cxcl13expressioninsalivarytissueincreaseswithdiseaseprogression,anditsblockaderesultedinamodestreductioninglandularinflammationinanSSmodel.WedemonstratethatinhumansCXCL13iselevatedinserumandsaliva,andanelevatedsalivaryCXCL13leveldistinguishespatientswithxerostomia.ThesedatasuggestaroleforCXCL13asavaluablebiomarkerinSS,as74%ofpatientswithSSdisplayedelevatedCXCL13insera,saliva,orboth.Thus,CXCL13maybepathogenicallyinvolvedinSSandmayserveasanewmarkerandapotentialtherapeutictarget...

【 授权许可】

CC BY