Tumor microenvironment converts plasmacytoid dendritic cells into immunosuppressive/tolerogenic cells: insight into the molecular mechanisms

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: antitumor immunity;    cancer;    immunosuppression;   

DOI  :  10.1189/jlb.0812397

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

HumanpDCsrepresentararepopulationofcirculatingcellscharacterizedbyarapidandmassiveTLR‐dependentsecretionoftypeIIFNinresponsetopathogenicagentsordangersignals.Throughtheircapacitytobringtogetherinnateandadaptiveimmunityandtosecretesolublefactorscontrollingcancerdevelopment,thesecellscouldrepresentimportantactorsinantitumorimmunity.However,accumulatingevidencesuggeststhatpDCsrecruitedtothetumormicroenvironmentoftendisplayanonactivatedstateandareassociatedwiththedevelopmentandmaintenanceofimmunosuppression.Here,wepresentanoverviewofneoplasticlesionsassociatedwithaninfiltrationofimmunosuppressive/tolerogenicpDC.Moreover,astheproperresponseofpDCagainstcancerdependsonacriticalbalancebetweenimmune‐activatingandimmune‐suppressingmechanisms,wesummarizecurrentknowledgeaboutthemolecularpathwaysdevelopedbytumorstopreventantitumoralpDCimmuneresponses.AbetterunderstandingofthemechanismsregulatingpDCfunctionintumorscouldaidinthedevelopmentofnewtherapies.Indeed,effectivecancervaccinesortherapiescouldcombineimmunoactivatingstrategies(i.e.,TLRagonists)witheliminationofimmune‐suppressingmechanisms,leadingtopDCreprogrammingandthus,allowingtumorrejectioninaclinicalsetting...

【 授权许可】

CC BY