| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Preterm neonates display altered plasmacytoid dendritic cell function and morphology | |
| 关键词: newborns; IFN‐; α; viral infections; TLR9; human; | |
| DOI : 10.1189/jlb.1011525 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Bacterialandviralinfectionscausehighratesofmorbidityandmortalityinprematurenewborns.Inthesettingofviralinfection,pDCsplayakeyroleasstrongproducersofIFN‐αuponTLR9activation.WeanalyzedpDCfrequency,phenotype,morphology,andfunctioninCBofpretermandtermnewbornsincomparisonwithadults.WhereasallagegroupsshowsimilarpDCnumbers,BDCA‐2,CD123,andTLR9levels,theexpressionofBDCA‐4andcapacitytoproduceIFN‐αuponTLR9challengeweredecreasedsignificantlyinpretermneonates.Furthermore,weshowbymeansofelectronmicroscopythatpDCsfrompretermnewbornsexhibitadistinct,“immature”morphology.Takentogether,thesefindingssuggestdecreasedfunctionalityofpDCsintheprematurenewborn.ThereducedcapacitytoproduceIFN‐αislikelytorendersuchinfantsmoresusceptibletoviralinfections...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901232410027ZK.pdf | 2336KB |  download |
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