Mammary carcinoma with osteoclast-like giant cells: a case report

International Journal of Clinical and Experimental Pathology

Alia Saeed Albawardi¹ 

关键词: Mammary carcinoma;    osteoclast like giant cells;    estrogen receptor (ER);    progesterone receptor (PR);    human epidermal growth factor receptor 2 (Her2/neu);    receptor activator of nuclear-kB expression (RANK);    RANK ligand (RANKL) expression;    matrix metalloproteinase 1 (MMP1);   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Mammary carcinoma with osteoclast-like giant cells is rare, and comprises less that 2% of breast carcinoma cases. Herein, we present a case of a 45-year-old woman who underwent breast lumpectomy and sentinel lymph node biopsy for a solitary well defined breast tumor. Histological examination revealed an invasive tumor composed of ducts, small nests and cribriform formations intermixed with a prominent osteoclast like giant cell component. The background stroma is hemorrhagic with conspicuous hemosiderin deposition. The paper will outline the clinico-pathologic characteristic features of this uncommon subtype as well as the current understanding on the pathogenesis of the osteoclast-like giant cells. The invasive carcinoma and the osteoclast-like giant cells staining patterns using immunohistochemical stains for estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, receptor activator of nuclear-kB, RANK ligand, and matrix metalloproteinase 1 are reported.

【 授权许可】

CC BY-NC