The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function

American journal of clinical and experimental immunology

Thomas Noonan¹ 

关键词: Vascular adhesion protein-1 (VAP-1);    semicarbazide-sensitive amine oxidase;    immune cell trafficking;    oxidase activity;    inflammatory function;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Vascular adhesion protein-1 (VAP-1) has been implicated in the pathogenesis of inflammatory diseases and is suggested to play a role in immune cell trafficking. It is not clear whether this effect is mediated by the oxidase activity or by other features of the protein such as direct adhesion. In order to study the role of VAP-1 oxidase activity in vivo, we have generated mice carrying an oxidase activity-null VAP-1 protein. We demonstrate that the VAP-1 oxidase null mutant mice have a phenotype similar to the VAP-1 null mice in animal models of sterile peritonitis and antibody induced arthritis suggesting that the oxidase activity is responsible for the inflammatory function of VAP-1.

【 授权许可】

CC BY-NC