Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: leukocyte adhesion deficiency;    integrins;    Del‐;    1;    complement;    IL‐;    17;   

DOI  :  10.1189/jlb.3VMR1014-468R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Onceviewedassimplyantibacterialeffectorcellspackedwithantimicrobials,neutrophilsarenowincreasinglyappreciatedfortheirregulatoryrolesinimmunityandinflammation.Thehomeostaticregulationofneutrophilsisthuscrucialforoptimaloperationoftheimmunesystem.Anattractivemodeltounderstandmechanisticallytheroleofneutrophilsisperiodontitis,anoralinflammatorydiseasethatisparticularlysensitivetoneutrophilalterationsinnumbersorfunction.Therecruitmentandproperactivationofneutrophilsarelargelydependentonleukocyteintegrinsandcomplement.Thisreviewdiscusseshowtheseprocessesareaffectedbyhostgeneticormicrobialfactorsleadingtothedevelopmentofperiodontitis.Forinstance,bothhypo‐andhyper‐recruitmentofneutrophilsasaresultofdeficienciesintheexpressionofβ2integrinsortheirnegativeregulators,respectively,causesunwarrantedIL‐17‐dependentinflammatoryboneloss.Moreover,microbialhijackingofC5aR(CD88)signalinginneutrophilsimpairstheirantimicrobialfunctionwhilepromotingdestructiveinflammatoryresponses.Thesestudiesnotonlysupporttheconceptthatneutrophilhomeostasisiskeytoperiodontalhealthbutalsorevealpromising,newtherapeutictargetsasdiscussedinthereview...

【 授权许可】

CC BY