Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: inflammation;    sex difference;    zymosan;    monocyte;    neutrophil;   

DOI  :  10.1189/jlb.3A1214-601RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Sexualdimorphismsexistintheincidenceandseverityofmanydiseases,withfemalesdemonstratingrelativeprotectionfrominflammatoryconditions.Theextentandmechanismsbywhichexcessiveleukocyterecruitmentunderliesthesedifferencesarenotwellestablished,andbetterunderstandingisessentialforthedevelopmentoftargetedtherapies.Here,wesetouttocomparethemaleandfemaleinflammatoryresponseinamurinezymosan‐inducedperitonitismodelandtounderstandhowleukocytesubsetsaremobilizedfromstoragepoolsinbothsexes.ThisworkshowsthatfemaleC57BL/6micerecruitfewerclassicalmonocytesandneutrophilsduringzymosan‐inducedperitonitis.Inaddition,sexdifferenceswereevidentinthecirculation,asfemalemiceshowedreducedneutrophiliaandmonocytosisvs.malecounterparts,despitehavingsimilarmobilizationfromBMstores.Importantly,weshowthatstorageandtraffickingofsplenicleukocytesduringacuteinflammationaredistinctbetweenthesexes.Malemicehavegreatersplenicstoresofneutrophilsandclassicalandnonclassicalmonocytes,despitesimilarspleensizes,signifyinganothersourceofpotentialpathogenicleukocytes.Thisworkdemonstratesthatmalesandfemaleshavedistinctleukocyte‐traffickingprofilesinacuteinflammationandsuggeststhatthespleen,nottheBM,playsaroleindeterminingsexdifferencesintheavailablepoolofimmunecells.Suchdimorphismsdemonstratetheimportanceofconsideringgenderinassaydevelopment,drugdesign,andclinicaltrials...

【 授权许可】

CC BY