Macrophage phenotypes during tissue repair

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: wound healing;    inflammation;    cell therapy;    fibrosis;    M2a;    regeneration;   

DOI  :  10.1189/jlb.1012512

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Mparecrucialfortissuerepairandregenerationbutcanalsocontributetotissuedamageandfibrosis.Mpcanadoptavarietyoffunctionalphenotypesinresponsetodifferentstimuli;twoofthebest‐characterizedinvitrophenotypesareaproinflammatory“M1”phenotype,producedbyexposuretoIFN‐γandTNF‐α,andananti‐inflammatory“M2a”phenotype,producedbyIL‐4orIL‐13.M2aMparefrequentlytermed“woundhealing”Mp,astheyexpressfactorsthatareimportantfortissuerepair.ThisreviewwillsummarizecurrentknowledgeofMpphenotypesduringtissuerepairandwillarguethattheseinvivoMppopulationsareheterogeneousandtemporallyregulatedanddonotconformtoexisting,invitro‐definedM1orM2phenotypes.Mpduringtheearlystagesoftissuerepairexhibitamoreproinflammatoryphenotypethantheirlatercounterparts,whichinturnmayexhibitsomeM2a‐associatedcharacteristics.However,phenotypicmarkersthatappeartobecoregulatedinculturedMpcanbeexpressedindependentlyofeachotherinvivo.Additionally,M1‐andM2‐associatedmarkersmaybeexpressedsimultaneouslybyactualtissue‐repairMp.ImprovedunderstandingofMpphenotypesandtheirregulationmayassistingenerationofnoveltherapiesbasedonmanipulatingMpfunctiontoimprovehealing...

【 授权许可】

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