Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
The effect of adenovirus‐specific antibodies on adenoviral vector–induced, transgene product–specific T cell responses | |
关键词: HIV vaccine; AdHu5 immune serum; STEP trial; adenovirus hexon; virus neutralizing antibodies; | |
DOI : 10.1189/jlb.1A0813-451RR | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Inthisstudy,wetestedtheeffectofneutralizingAbstodifferentserotypesofE1‐deletedAdvectorsontheimmunogenicityofthehomologousAdvectororavectorderivedfromaheterologousserotype.Ourresultsshowedthat,asexpected,evenlowtitersofpassivelytransferredneutralizingAbssignificantlyreducedthehomologousvectors'abilitytoelicittransgene‐specificCD8+Tcellresponses.Inaddition,Abschangedthefateoftransgeneproduct–specificCD8+Tcellsbypromotingtheirtransitionintothecentralmemorycellpool,whichresultedinmarkedlyenhancedexpansionoftransgeneproduct–specificCD8+TcellsafteraboostwithaheterologousAdvector.Non‐neutralizingAbsspecifictoadistinctAdserotypehadnoeffectonthemagnitudeoftransgeneproduct‐specificCD8+TcellsinducedbyaheterologousAdvector,nordidsuchAbspromoteinductionofmorerestingmemoryCD8+Tcells.TheseresultsshowthatAbstoanAdvaccinecarrieraffectnotonlythemagnitudebutalsotheprofileofavector‐inducedCD8+Tcellresponse...
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201901231137152ZK.pdf | 2000KB | download |