The effect of adenovirus‐specific antibodies on adenoviral vector–induced, transgene product–specific T cell responses

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: HIV vaccine;    AdHu5 immune serum;    STEP trial;    adenovirus hexon;    virus neutralizing antibodies;   

DOI  :  10.1189/jlb.1A0813-451RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Inthisstudy,wetestedtheeffectofneutralizingAbstodifferentserotypesofE1‐deletedAdvectorsontheimmunogenicityofthehomologousAdvectororavectorderivedfromaheterologousserotype.Ourresultsshowedthat,asexpected,evenlowtitersofpassivelytransferredneutralizingAbssignificantlyreducedthehomologousvectors'abilitytoelicittransgene‐specificCD8+Tcellresponses.Inaddition,Abschangedthefateoftransgeneproduct–specificCD8+Tcellsbypromotingtheirtransitionintothecentralmemorycellpool,whichresultedinmarkedlyenhancedexpansionoftransgeneproduct–specificCD8+TcellsafteraboostwithaheterologousAdvector.Non‐neutralizingAbsspecifictoadistinctAdserotypehadnoeffectonthemagnitudeoftransgeneproduct‐specificCD8+TcellsinducedbyaheterologousAdvector,nordidsuchAbspromoteinductionofmorerestingmemoryCD8+Tcells.TheseresultsshowthatAbstoanAdvaccinecarrieraffectnotonlythemagnitudebutalsotheprofileofavector‐inducedCD8+Tcellresponse...

【 授权许可】

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