A tale of two sites: how inflammation can reshape the microbiomes of the gut and lungs

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: nitrate reduction;    E. coli ;    P. aeruginosa ;    cystic fibrosis;    inflammatory bowel disease;   

DOI  :  10.1189/jlb.3MR0316-106R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Inflammationcandirectlyandindirectlymodulatethebacterialcompositionofthemicrobiome.Althoughstudiesofinflammationprimarilyfocusonitsfunctiontonegativelyselectagainstpotentialpathogens,somebacterialspecieshavetheabilitytoexploitinflammatorybyproductsfortheirbenefit.Inflammatorycellsreleasereactivenitrogenspeciesasantimicrobialeffectorsagainstinfection,butsomefacultativeanaerobescanalsoutilizetheincreaseinextracellularnitrateintheirenvironmentforanaerobicrespirationandgrowth.Thisphenomenonhasbeenstudiedinthegastrointestinaltract,wherebloomsoffacultativeanaerobicGammaproteobacteria,primarilyEscherichiacoli,oftenoccurduringcolonicinflammation.Incysticfibrosis,Pseudomonasaeruginosa,anotherGammaproteobacteriafacultativeanaerobe,canreducenitrogenforanaerobicrespirationanditbloomsintheairwaysofthechronicallyinflamedcysticfibrosislung.Thisreviewfocusesontheevidencethatinflammationcanprovideterminalelectronacceptorsforanaerobicrespirationandcansupportbloomsoffacultativeanaerobes,suchasE.coliandP.aeruginosaindistinct,butsimilar,environmentsoftheinflamedgastrointestinalandrespiratorytracts...

【 授权许可】

CC BY