Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury | |
关键词: artery occlusion; oxygen‐; free radicals; apoptosis; adhesion molecules; | |
DOI : 10.1189/jlb.0609438 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
LXRisanothermemberofthesuperfamilyofnuclearhormonereceptorsthatheterodimerizeswithRXRandregulatestheintracellularlevelsofcholesterolthroughgeneinductionofenzymesandproteinsinvolvedinthecholesterolmetabolismandtransport.LXRligandsinhibitthegeneexpressionofproinflammatorymediatorsinimmunostimulatedmacrophages;invivostudieshaveshownthatactivationofLXRreducestheinflammatoryresponseinamurinemodelofcontactdermatitisandatherosclerosis.NoreportshaveaddressedaroleforLXRsinpathophysiologyofintestinalischemia.TheaimofthisstudywastoinvestigatetheeffectsofT0901317,apotentLXRligand,inamousemodelofSAOshock,whichwasinducedbyclampingthesuperiormesentericarteryandtheceliactrunk,resultinginatotalocclusionofthesearteriesfor30min.Afterthisperiodofocclusion,theclampswereremoved.Micewerekilledat60minafterreperfusion.ThisstudyprovidestheevidencethatT0901317,LXRagonist,modulates:thedevelopmentofSAOshock;theinfiltrationofthetissuewithPMNs;theexpressionofTNF‐αandIL‐1β;thenitrationoftyrosineresidues;NF‐κBexpression;theMAPKphosphorylation(ERK,JNK,andp38);FasL;apoptosis;BaxandBcl‐2expression;andthedegreeoftissueinjurycausedbySAOshock.OurresultsimplythatLXRagonistsmaybeusefulinthetherapyofinflammation...
【 授权许可】
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