At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: NK cells;    Haploidentical hematopoietic stem cell transplantation;    γ;    ‐;    δ;    T cells;    graft‐;    versus‐;    host disease;    graft‐;    versus‐;    leukemia effect;   

DOI  :  10.1189/jlb.0613343

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Theidentificationofananti‐tumoreffectdisplayedbycellsofinnateimmunityhasopenednewscenarios,notonlyinthefieldofallo‐HSCTbutalsofornontransplantedpatientswithhematologicalmalignanciesorsolidtumors.Donor‐derivedNKcellshavebeenshowntocontributetotheeradicationofmalignantcellsafterallo‐HSCT,whenrecipientslackligandsfortheirinhibitoryreceptors.ThesealloreactivedonorNKcellscanalsokillrecipientAPCsandCTLs,thuspreventingtheoccurrenceofGvHDandgraftrejection.TheroleofactivatingreceptorsonthecapacityofNKcellstokillleukemiatargetshasbecomeevidentinthelastyears.Theadoptiveinfusionofexvivo‐activatedNKcellshasbeeninvestigatedrecentlyinPhaseI/IItrialsonpatientswithhematologicalmalignanciesandsolidtumors,withpromisingresults.γδTlymphocytesarealsoabletodisplayanti‐tumoractivity—thisprovidingthebiologicalrationaleforPhaseI/IItrialsinlymphoproliferativedisordersandsolidtumors.AminobisphosphonatesareclinicallyavailablecompoundsabletoboostγδTcellfunction.AsγδTcellsdonotcauseGvHD,theycouldalsobetransducedwithtumor‐associatedchimericantigenreceptorsandsafelyinfusedinallo‐HSCTrecipients.Basicaspectsofinnateimmunityrelevanttothefieldwillbecoveredbyacompanionreviewarticle...

【 授权许可】

CC BY