Early‐onset age‐related changes in dendritic cell subsets can impair antigen‐specific T helper 1 (Th1) CD4 T cell priming

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: OX40;    aging;    vesicular stomatitis virus;    T‐;    bet;   

DOI  :  10.1189/jlb.1A0114-066R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

DeclineinCD4Tcellimmuneresponsesisassociatedwithaging.Althoughanumberofimmunologicaldefectshavebeenidentifiedinelderlymice(>18monthsold),akeyearly‐onsetimmunedefectatmiddleagecouldbeadriverorcontributortodefectiveCD4Tcellresponses.Ourstudiesdemonstratethatage‐relatedalterationsinDCsubsetswithintheprimingenvironmentofmiddle‐agedmice(12monthsold)correlatewithandcandirectlycontributetodecreasesinantigen‐specificCD4TcellTh1differentiation,whichmeasuredbyT‐betandIFN‐γexpression,wasdecreasedsignificantlyinTcellsfollowingVSVinfectionors.c.immunizationwithaproteinantigeninthecontextofimmunestimulationviaOX40.ThedeficientTh1phenotype,observedfollowingproteinantigenchallenge,wasfoundtobetheresultofanage‐relateddecreaseinaninflammatoryDCsubset(CD11b+Gr‐1/Ly6C+)inthedLNthatcorrespondedwithTcelldysfunction.Inthevirusmodel,weobservedsignificantchangesintwoDCsubsets:mDCsandpDCs.Thus,different,earlyage‐relatedchangesintheDCprofileintheprimingenvironmentcansignificantlycontributetoimpairedTh1differentiation,dependingonthetypeofimmunologicalchallenge...

【 授权许可】

CC BY