Response: “Commentary: A Hypothesis for Examining Skeletal Muscle Biopsy-Derived Sarcolemmal nNOSµ as Surrogate for Enteric nNOSα Function”. nNOSskeletal muscle may be Evidentiary for Enteric NO-Transmission Despite nNOSµ/α Differences

Frontiers in Medicine

Arun Chaudhury¹ 

关键词: skeletal muscle;    membrane nNOS;    active site;    splice;    nitrergic;    biomarker;    biopsy;   

DOI  :  10.3389/fmed.2016.00004

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Accommodation of food/liquid bolus or chyme/chyle within the esophagogastrointestinal lumen necessitates relaxation of the muscular wall (1–3). This relaxation is mediated by two neurotransmitters released in tandem from the nerve terminals that are in microscale proximity to the smooth muscles. Sequential evoked release of soluble purine derivatives, notably ATP and de novo synthesized gaseous nitric oxide (NO) relaxes the smooth muscles (4, 5). The mechanical relaxation is preceded by an electrical event, the inhibitory junction potential (IJP), which is the sine qua non of enteric musculomotor inhibitory neurotransmission (6–8).1 Regional movement also necessitates contraction of the smooth muscles mediated by cholinergic muscarinic stimulation but throughout the gastrointestinal tract, “inhibitory neurotransmission-mediated accommodation” is the single most important functional component that allows oro-aboral accommodation and progression of gut contents (9). Not surprisingly, the disorders pertaining to gastrointestinal motility mainly results from defects in accommodation, chiefly due to impairment of inhibitory neurotransmission (1, 10–12).

【 授权许可】

CC BY