Evidence of Increase in Mortality After the Introduction of Diphtheria–Tetanus–Pertussis Vaccine to Children Aged 6–35 Months in Guinea-Bissau: A Time for Reflection?

Frontiers in Public Health

Peter Aaby¹ 

关键词: bias in vaccine studies;    diphtheria–;    tetanus–;    pertussis vaccine;    heterologous effects;    measles vaccine;    non-specific effects of vaccines;    oral polio vaccine;   

DOI  :  10.3389/fpubh.2018.00079

学科分类：卫生学

来源: Frontiers

【 摘 要 】

BackgroundWhole-cell diphtheria–tetanus–pertussis (DTP) and oral polio vaccine (OPV) were introduced to children in Guinea-Bissau in 1981. We previously reported that DTP in the target age group from 3 to 5 months of age was associated with higher overall mortality. DTP and OPV were also given to older children and in this study we tested the effect on mortality in children aged 6–35 months.

【 授权许可】

CC BY