Salivary biomarkers may measure stress responses in critically ill children:

SAGE Open Medicine

DespoinaTzira¹ 

关键词: Salivary cortisol;    amylase;    IgA;    stress;    pediatric critical illness;   

DOI  :  10.1177/2050312118802452

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objective:Measurement of salivary biomarkers can provide important information regarding hypothalamic–pituitary–adrenal axis activity both under normal conditions as well as in response to psychological or physical stress. Our aim was to correlate salivary stress markers, such as cortisol, α-amylase and immunoglobulin A, with the Pediatric Risk Index Score of Mortality, underlying disease (pathologic, trauma and postoperative), need for mechanical ventilation/sedation and time lag between onset of illness and admission in children admitted in the pediatric intensive care unit.Methods:We enrolled 79 pediatric intensive care unit patients (2–14 years) over a 2-year period, which satisfy the including criteria, but finally salivary biomarkers were evaluated in 65 patients. Saliva samples were collected within 24 h of admission at 8 a.m., 2 p.m. and 8 p.m. to examine potential disruption of circadian rhythm.Results:Overall, the salivary biomarkers were increased; specifically, median values were (a) cortisol ...

【 授权许可】

CC BY