Acute Myeloid Leukemia in Infants: Biology and Treatment

Frontiers in Pediatrics

Riccardo Masetti¹ 

关键词: acute myeloid leukemia;    infants;    prognostic factors;    toxicity;    hematopoietic stem cell transplantation;    treatment results;   

DOI  :  10.3389/fped.2015.00037

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Children aged 0–2 years (i.e., infants) with acute myeloid leukemia (AML) are a peculiar subgroup of patients in the childhood AML scenario. They present with distinctive biological and clinical characteristics, including a high prevalence of prognostically unfavorable risk factors and an increased susceptibility to therapy-related toxicity. Remarkable improvements have been achieved over the last two decades in the treatment of these patients and their outcome is becoming superimposable to that of the older age groups. In this review, we will focus on peculiarities of this young subgroup of children with AML, describing their clinical presentation, the biology of disease, and factors influencing outcome. Treatment results and toxicity data reported by major collaborative groups are also summarized and compared.

【 授权许可】

CC BY