Model of Human Fetal Growth in Hypoplastic Left Heart Syndrome: Reduced Ventricular Growth Due to Decreased Ventricular Filling and Altered Shape

Frontiers in Pediatrics

Sukriti Dewan¹ 

关键词: HLHS;    growth hormone;    biomechanics;    sarcomeres;    computational model;    patient-specific modeling;    mechanobiology;   

DOI  :  10.3389/fped.2017.00025

学科分类：儿科学

来源: Frontiers

【 摘 要 】

IntroductionHypoplastic left heart syndrome (HLHS) is a congenital condition with an underdeveloped left ventricle (LV) that provides inadequate systemic blood flow postnatally. The development of HLHS is postulated to be due to altered biomechanical stimuli during gestation. Predicting LV size at birth using mid-gestation fetal echocardiography is a clinical challenge critical to prognostic counseling.

【 授权许可】

CC BY