Polymorphisms in TLR9 but not in TLR5 increase the risk for duodenal ulcer and alter cytokine expression in the gastric mucosa:

Innate Immunity

AlejandraTrejo-de la O¹ 

关键词: Duodenal ulcer;    gastric cancer;    Helicobacter pylori;    single-nucleotide polymorphisms;    Toll-like receptor 9;   

DOI  :  10.1177/1753425915587130

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Colonization of the gastric mucosa by Helicobacter pylori can lead to peptic ulcer and gastric adenocarcinoma. TLRs are signaling receptors involved in the recognition of microorganisms, and polymorphisms in their genes may influence the innate and adaptive immune response to H. pylori, affecting the clinical outcomes of the infection. We assessed the association between single nucleotide polymorphisms in TLR9 and TLR5 and gastroduodenal diseases. All patients were genotyped by allelic discrimination in regions 1174C > T and 1775A > G of TLR5 and −1237T > C and 2848G > A of TLR9. The 2848A allele of TLR9 was more frequent in duodenal ulcer and showed an association of risk with this pathology. Polymorphisms in TLR5 were not found to be associated with disease. Patients with polymorphisms in TLR9 and TLR5 expressed significantly lower levels of IL-1β and TNF-α, whereas polymorphisms in TLR5 also decreased the expression of IL-6 and IL-10. Our findings suggest that 2848G > A polymorphism in TLR9 increases t...

【 授权许可】

CC BY