Chromogranin A and cortisol at intraoperative repeated noxious stimuli: Surgical stress in a dog model:

SAGE Open Medicine

Odd VikingHöglund¹ 

关键词: Sympathetic nervous system;    sympathetic tone;    biomarkers;    chromogranin A;    cortisol;    ovariohysterectomy;   

DOI  :  10.1177/2050312115576432

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objectives:Biomarkers representing sympathetic tone and the surgical stress response are measured to objectively evaluate surgical techniques and anaesthetic protocols. If a part of the intraoperative procedure is repeated on the contralateral organ, one animal may potentially serve as its own control and, if so, may minimize the problem of individual differences of the stress response to anaesthesia and surgery. This study aimed to investigate the use of chromogranin A for measurement of the intraoperative sympathetic tone. Additional aims were to investigate chromogranin A and cortisol as indicators of the intraoperative surgical stress response caused by repeated noxious stimuli in dogs subjected to ovariohysterectomy and thereby to investigate the possibility of one dog serving as its own control.Methods:Experiments were carried out on 10 dogs subjected to ovariohysterectomy. Perioperative blood samples (0–6) were collected after premedication, immediately before induction of anaesthesia (0), after in...

【 授权许可】

CC BY