Inflammation in dry eye associated with rheumatoid arthritis: Cytokine and in vivo confocal microscopy study:

Innate Immunity

EdoardoVillani¹ 

关键词: Rheumatoid arthritis;    Sjögren’s syndrome;    dry eye;    confocal microscopy;    inflammation;   

DOI  :  10.1177/1753425912471692

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The purpose of this research was to study ocular surface inflammation in relation to systemic disease activity in rheumatoid arthritis (RA) patients with or without secondary Sjögren’s syndrome (SSII and non-SSII respectively). The study was conducted in two phases. In phase I, 12 patients with active RA SSII and 12 with active RA non-SSII were consecutively enrolled. Each completed an Ocular Surface Disease Index (OSDI) questionnaire and underwent a full eye exam and in vivo confocal microscopy examination of the cornea. Tear fluid samples were collected in sponges and analyzed for IL-1α, -6, and -8, and TNF-α. When RA activity was suppressed by systemic treatment the patients entered phase II of the study in which all of the phase I examinations were repeated. In RA SSII patients, OSDI, fluorescein staining dendritic cell density, and concentrations of IL-1α and IL-6 decreased significantly (P < 0.01) between phases I and II. Tear breakup time scores increased significantly. For RA non-SSII patients, th...

【 授权许可】

CC BY