Vasopressin and Terlipressin in the Treatment of Vasodilatory Septic Shock: A Systematic Review:

Proceedings of Singapore Healthcare

Jie LinSoong¹ 

关键词: distributive;    sepsis;    shock;    terlipressin;    vasodilatory;    vasopressin;   

DOI  :  10.1177/201010581102000310

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:Vasodilatory septic shock unresponsive to fluid resuscitation requires the addition of vasopressors. Catecholamines remain the first line vasopressor therapy, but treatment failure is a potential problem. Vasopressin and its analogue, terlipressin, have been used for this indication.Objective:This systematic review aims to evaluate the effects of vasopressin and terlipressin on mortality and morbidity outcomes in patients with vasodilatory shock. Secondary outcomes include the effects of vasopressin and terlipressin on haemodynamic stability and organ function.Method:A computerised search of MEDLINE from January 1966 till June 2010 and screening of references of relevant articles were conducted. Only prospective, randomised controlled trials comparing vasopressin or terlipressin versus standard vasopressors or placebo were included.Results:Seven studies using vasopressin, three using terlipressin and one using both were identified. Four vasopressin trials assessing mortality and morbidity outco...

【 授权许可】

CC BY