Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions:

SAGE Open Medicine

VincentAmoah¹ 

关键词: Cardiovascular;    chronic total occlusion;    vascular endothelial growth factor;    hypoxia-inducible factor-1α;    Rentrop grade;    gene polymorphism;    polymerase chain reaction;   

DOI  :  10.1177/2050312116654403

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Introduction:We evaluated the association between two single nucleotide polymorphisms of the vascular endothelial growth factor gene and one of the hypoxia-inducible factor-1α gene and the degree of coronary collateral formation in patients with a coronary chronic total occlusion.Methods:Totally, 98 patients with symptomatic coronary artery disease and a chronic total occlusion observed during coronary angiography were recruited. Genotyping of two vascular endothelial growth factor promoter single nucleotide polymorphisms (−152G>A and −165C>T) and the C1772T single nucleotide polymorphism of hypoxia-inducible factor-1α were performed using polymerase chain reaction and restriction fragment length polymorphism analysis. The presence and extent of collateral vessel filling was scored by blinded observers using the Rentrop grade.Results:We found no association between the vascular endothelial growth factor −152G>A, −165C>T and hypoxia-inducible factor-1α −1772C>T with the presence and filling of coronary col...

【 授权许可】

CC BY