SAGE Open Medicine | |
Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions: | |
VincentAmoah1  | |
关键词: Cardiovascular; chronic total occlusion; vascular endothelial growth factor; hypoxia-inducible factor-1α; Rentrop grade; gene polymorphism; polymerase chain reaction; | |
DOI : 10.1177/2050312116654403 | |
学科分类:医学(综合) | |
来源: Sage Journals | |
【 摘 要 】
Introduction:We evaluated the association between two single nucleotide polymorphisms of the vascular endothelial growth factor gene and one of the hypoxia-inducible factor-1α gene and the degree of coronary collateral formation in patients with a coronary chronic total occlusion.Methods:Totally, 98 patients with symptomatic coronary artery disease and a chronic total occlusion observed during coronary angiography were recruited. Genotyping of two vascular endothelial growth factor promoter single nucleotide polymorphisms (−152G>A and −165C>T) and the C1772T single nucleotide polymorphism of hypoxia-inducible factor-1α were performed using polymerase chain reaction and restriction fragment length polymorphism analysis. The presence and extent of collateral vessel filling was scored by blinded observers using the Rentrop grade.Results:We found no association between the vascular endothelial growth factor −152G>A, −165C>T and hypoxia-inducible factor-1α −1772C>T with the presence and filling of coronary col...
【 授权许可】
CC BY
【 预 览 】
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RO201901226981663ZK.pdf | 91KB | download |