BMP4 and LGL1 are Down Regulated in an Ovine Model of Congenital Diaphragmatic Hernia

Frontiers in Surgery

Heather M. A. Emmerton-Coughlin¹ 

关键词: congenital diaphragmatic hernia;    pulmonary hypoplasia;    sheep;    Wnt;    BMP4;    LGL1;   

DOI  :  10.3389/fsurg.2014.00044

学科分类：外科医学

来源: Frontiers

【 摘 要 】

Background/Purpose: The molecular pathophysiology of lung hypoplasia in congenital diaphragmatic hernia (CDH) remains poorly understood. The Wnt signaling pathway and downstream targets, such as bone morphogenetic proteins (BMP) 4 and other factors such as late gestation lung protein 1 (LGL1), are essential to normal lung development. Nitrofen-induced hypoplastic CDH rodent lungs demonstrate down regulation of the Wnt pathway including BMP4 and reduced LGL1 expression. The aim of the current study was to examine the molecular pathophysiology associated with a surgically induced CDH in an ovine model.

【 授权许可】

CC BY