SAGE Open Medicine | |
Sitagliptin ameliorates the progression of atherosclerosis via down regulation of the inflammatory and oxidative pathways: | |
Sahar AMajeed1  | |
关键词: Sitagliptin; atherosclerosis; oxidative stress; inflammation; | |
DOI : 10.1177/2050312113499912 | |
学科分类:医学(综合) | |
来源: Sage Journals | |
【 摘 要 】
Back ground:Atherosclerosis is the major cause of death. The most common risk factors are hyperlipidemia, diabetes, and other factors like chronic infection and inflammation.Objective:This study was undertaken to assess the effect of sitagliptin on atherosclerosis via interfering with inflammatory and oxidative pathways.Materials and Methods:A total of 18 local domestic male rabbits were included in this study. The animals were randomly divided into three groups (6 rabbits in each group): Group I normal were fed with chow (oxiod) diet for 12 weeks. Group II were fed with 1% cholesterol enriched diet for 12 weeks. Group III rabbits fed with cholesterol enriched diet for 6 weeks, and then continued on cholesterol enriched diet and treated with sitagliptin 125 mg/kg/day orally for the next 6 weeks. Blood samples were collected at the start of the study, at 6 weeks of the study and then at the end of treatment to measure serum lipids profile, hsCRP and TNFα. At end of the study, the aorta was removed for meas...
【 授权许可】
CC BY
【 预 览 】
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RO201901225995788ZK.pdf | 261KB | download |