Sitagliptin ameliorates the progression of atherosclerosis via down regulation of the inflammatory and oxidative pathways:

SAGE Open Medicine

Sahar AMajeed¹ 

关键词: Sitagliptin;    atherosclerosis;    oxidative stress;    inflammation;   

DOI  :  10.1177/2050312113499912

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Back ground:Atherosclerosis is the major cause of death. The most common risk factors are hyperlipidemia, diabetes, and other factors like chronic infection and inflammation.Objective:This study was undertaken to assess the effect of sitagliptin on atherosclerosis via interfering with inflammatory and oxidative pathways.Materials and Methods:A total of 18 local domestic male rabbits were included in this study. The animals were randomly divided into three groups (6 rabbits in each group): Group I normal were fed with chow (oxiod) diet for 12 weeks. Group II were fed with 1% cholesterol enriched diet for 12 weeks. Group III rabbits fed with cholesterol enriched diet for 6 weeks, and then continued on cholesterol enriched diet and treated with sitagliptin 125 mg/kg/day orally for the next 6 weeks. Blood samples were collected at the start of the study, at 6 weeks of the study and then at the end of treatment to measure serum lipids profile, hsCRP and TNFα. At end of the study, the aorta was removed for meas...

【 授权许可】

CC BY