CXC chemokine ligand 4 (CXCL4) down-regulates CC chemokine receptor expression on human monocytes:

Innate Immunity

FranziskaSchwartzkopff¹ 

关键词: CCR1;    −2;    −5;    CXCL4;    chemokine release;    human monocytes;    heterologous receptor down-regulation;   

DOI  :  10.1177/1753425910388833

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

During acute inflammation, monocytes are essential in abolishing invading micro-organisms and encouraging wound healing. Recruitment by CC chemokines is an important step in targeting monocytes to the inflamed tissue. However, cell surface expression of the corresponding chemokine receptors is subject to regulation by various endogenous stimuli which so far have not been comprehensively identified. We report that the platelet-derived CXC chemokine ligand 4 (CXCL4), a known activator of human monocytes, induces down-regulation of CC chemokine receptors (CCR) 1, −2, and −5, resulting in drastic impairment of monocyte chemotactic migration towards cognate CC chemokine ligands (CCL) for these receptors. Interestingly, CXCL4-mediated down-regulation of CCR1, CCR2 and CCR5 was strongly dependent on the chemokine’s ability to stimulate autocrine/paracrine release of TNF-α. In turn, TNF-α induced the secretion CCL3 and CCL4, two chemokines selective for CCR1 and CCR5, while the secretion of CCR2-ligand CCL2 was T...

【 授权许可】

CC BY