Innate Immunity | |
The matri-cellular proteins ‘cysteine-rich, angiogenic-inducer, 61’ and ‘connective tissue growth factor’ are regulated in experimentally-induced sepsis with multiple organ dysfunction: | |
Claus VBHviid1  | |
关键词: Connective tissue growth factor; cysteine-rich; angiogenic inducer; 61; multiple organ failure; nephroblastoma overexpressed gene; sepsis; | |
DOI : 10.1177/1753425912436764 | |
学科分类:生物科学(综合) | |
来源: Sage Journals | |
【 摘 要 】
Organ failure is a severe complication in sepsis for which the pathophysiology remains incompletely understood. Recently, the matri-cellular cysteine-rich, angiogenic induced, 61 (Cyr61/CCN1); connective tissue growth factor (Ctgf/CCN2); and nephroblastoma overexpressed gene (Nov/CCN3) (CCN)-protein family have been attributed organ-protective properties. Their expression is sensitive to mediators of sepsis pathophysiology but a potential role in sepsis remains elusive. To provide an initial assessment, 50 rats were subjected to 18 h of cecal-ligation and puncture or sham operation. Hepatic and pulmonary CCN1 mRNA displayed an average 7.4- and 3.3-fold induction, while its cardiac expression was unchanged. The changes coincided with excessive hepatic and pulmonary inflammatory gene activation and a restricted cardiac inflammation. Furthermore, hepatocytes displayed a dosage-dependent CCN1 mRNA response in vitro, supporting a cytokine-mediated CCN1 regulation in sepsis. CCN2 mRNA was 2.2-fold induced in th...
【 授权许可】
CC BY
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Files | Size | Format | View |
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RO201901225919561ZK.pdf | 380KB | download |