Filifactor alocis manipulates human neutrophils affecting their ability to release neutrophil extracellular traps induced by PMA:

Innate Immunity

Cortney LArmstrong¹ 

关键词: Filifactor alocis;    human neutrophils;    neutrophil extracellular trap formation;    immunomodulation;    oral pathogens;   

DOI  :  10.1177/1753425918767507

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Neutrophils operate at the site of injury or inflammation in the periodontal pocket to ensure periodontal health and clearance of bacterial pathogens. Filifactor alocis is recently identified as a potential periodontal pathogen, and in this study, we assessed the formation of neutrophil extracellular traps (NETs), in response to the presence of the organism. NET formation by human neutrophils was not induced when challenged with F. alocis, independent of opsonization, viability, time, or bacterial dose. F. alocis also failed to induce NETs from TNF-α-primed neutrophils and did not induce the release of extracellular neutrophil elastase. However, significant NET induction was observed when neutrophils were challenged with Streptococcus gordonii or Peptoanaerobacter stomatis, In addition, co-infection studies revealed that the presence of F. alocis with S. gordonii or P. stomatis does not enhance or reduce NETs. Additionally, F. alocis failed to impact pre-formed NETs induced by either S. gordonii or P. sto...

【 授权许可】

CC BY